李莉娅

时间:2020-07-20浏览:11

李莉娅,副教授,博士生导师。20007月毕业于北京大学医学部,获药学本科学位;20067月毕业于北京大学医学部,获生药学博士学位,其后在首都医科大学中药学院从事中药化学教学与科研工作;20085月起在美国罗德岛大学药学院做博士后,20138月起在东北大学生命科学与健康学院任副教授。目前主要从事活性天然产物及功能性食品化学成分及生物活性的研究工作。旨在利用天然产物化学及食品营养学的研究手段从药食两用物质中发现能够防治慢性代谢性相关疾病的活性成分,探讨食源性天然活性成分对健康的促进作用及其作用机制。

联系方式

电子邮箱:lyli@mail.neu.edu.cn

科研项目

1.海南蒲桃抑制α-葡萄糖苷酶活性多酚类成分的发现及其降血糖作用研究2015.1-2017.12),国家自然科学基金青年基金(N31401473),主持。

2.药食两用资源降糖活性多酚成分挖掘及开发利用(2015.1-2016.12),教育部中央高校基本科研业务费(N142005002),主持。

3.两种桃金娘科药用植物中新型PTP1B抑制剂的发现及其构效关系研究(2017.1-2018.12),教育部中央高校基本科研业务费(N162004004),主持。

4.基于肠道微生态的海南蒲桃籽多酚预防营养性肥胖作用机制研究(2020.1-2021.12),教育部中央高校基本科研业务费(N2020005),主持。

近五年代表性论文

  1. Xu, W.; Zhang, L.; Omar, R.; Liu, W.; Wei, Z.; Zhang, Z.; Mu, Y.; Seeram, N. P.; Huang, X.; Ma, H.*; Li, L.* Barringtogenol C-type triterpenoid saponins from the stem bark of Norway maple (Acer platanoides). Planta Med., 86, 70-77, 2020.

  2. Li, Li.; Ma, H.; Liu, T.; Ding, Z.; Liu, W.; Gu, Q.; Mu, Y.; Xu, J.; Seeram, N. P.; Huang, X.; Xu, J. Glucitol-core containing gallotannins-enriched red maple (Acer rubrum) leaves extract alleviated obesity via modulating short-chain fatty acid production in high-fat diet-fed mice.J. Funct. Foods, 70 (7), 103970, 2020.

  3. Xu, J.; Liu, T.; Li, Y.; Liu, W.; Ding, Z.; Ma, H.; Seeram, N. P.; Mu, Y.; Huang, X.*; Li, L.*Jamun (Eugenia jambolana Lam.) fruit extract prevents obesity by modulating the gut microbiome in high-fat diet-fed mice. Mol. Nutr. Food Res., 63(9), 1801307, 2019.

  4. Li, Y.; Li, D.; An, Q.; Ma, H.; Mu, Y.; Qiao, W.; Zhang, Z.; Zhang, J.; Huang, X. *; Li, L.*New Acylated Phenolic Glycosides with ROS Scavenging Activity from Psidium guajava Leaves. J. Agric. Food Chem. 67 (40), 11089-11098, 2019.

  5. Xu, J.; Liu, T.; Li, Y.; Yuan, C.; Ma, H.; Seeram, N. P; Liu, F.; Mu, Y.; Huang, X.*; Li, L.* Hypoglycemic and Hypolipidemic Effects of Triterpenoid-Enriched Jamun (Eugenia jambolana Lam.) Fruit Extract in Streptozotocin-Induced Type 1 Diabetic Mice. Food Funct. 9 (6), 3330-3337, 2018.

  6. Liu, F.; Ma, H.; Wang, G.; Liu, W.; Seeram, N. P; Mu, Y.; Xu, Y.; Huang, X.*; Li, L.* Phenolics from Eugenia jambolana Seeds with Advanced Glycation Endproducts Formation and Alpha-Glucosidase Inhibitory Activities. Food Funct. 9 (8), 4246-4245, 2018.

  7. Xu, J.; Yuan, C.; Wang, G.; Luo, J.; Ma, H.; Xu, L.; Mu, Y.; Li, Y.; Seeram, N. P*; Huang, X.*; Li, L.* Urolithins Attenuate LPS-Induced Neuroinflammation in BV2Microglia via MAPK, Akt and NF-кB Signaling Pathways. J. Agric. Food Chem. 66 (3), 571-580, 2018.

  8. Xu, J. #; Li, L.#; Wang, Y.; Li, Y.; Shan, M.; Sun, S.; Yu, Y.; Wang, B.* Hepatocyte-specific deletion of BAP31 promotes SREBP1C activation, promotes hepatic lipid accumulation, and worsens IR in mice. J. Lipid Res. 59(1), 35-47, 2018. (共同第一作者)

  9. Liu, F.; Liu, C.; Liu, W.; Ding, Z.; Ma, H.; Seeram, N. P; Xu, L.; Mu, Y.; Huang, X.; Li, L.* New Sesquiterpenoids from Eugenia jambolana Seeds and Their Anti-Microbial Activities.J. Agric. Food Chem. 65 (47), 10214-10222, 2017.

  10. Li, Y.; Xu, J.; Yuan, C.; Ma, H.; Liu, T.; Liu, F.; Seeram, N. P.; Mu, Y.; Huang, X.*; Li, L.*Chemical Composition and Anti-hyperglycaemic Effects of Triterpenoid Enriched Eugenia jambolana Lam. Berry Extract. J. Funct. Foods, 28 (1), 1-10, 2017.

  11. Liu, F.; Yuan, T.; Liu, W.; Ma, H.; Seeram, N. P.; Li, Y.; Xu, L.; Mu, Y.; Huang, X.*; Li, L.* Phloroglucinol Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activities from Eugenia jambolana Seeds. J. Nat. Prod. 80 (2), 544-5502017.

  12. Li, L.; Cai, Y.; Jiang, Y.; Liu, J.; Ma, J.; Yuan, C.; Mu, Y.; Han, L.*; Huang, X. A Unique Macrolactam Derivative via a [4+6]-cycloaddition from Streptomyces niveus. Bioorg. Med. Chem. Lett. 26 (6), 1599-1604, 2016.

  13. Li, L.; Liu, R.; Han, L.; Jiang, Y.; Liu, J.; Li, Y.; Yuan, C.; Huang, X.* Structure determination of two new nerolidol-type sesquiterpenoids from the soil actinomycete Streptomyces scopuliridis. Magn. Reson. Chem. 54 (7), 606-609, 2016.

  14. Li, L.; Xu, J.; Mu, Y.; Han, L.; Liu, R.; Cai, Y.; Huang, X.* Chemical Characterization and Anti-hyperglycaemic Effects of Polyphenol Enriched Longan (Dimocarpus longan Lour.) Pericarp Extracts. J. Funct. Foods, 13 (1), 314-322, 2015.

专利

李莉娅,黄学石,韩力,许家林,一种具有抑制PTP1B活性的间苯三酚衍生物及其制备方法、应用,中国,ZL201710034516.1.