汪冰

时间:2020-07-20浏览:12

汪冰教授,1986年毕业于中国药科大学生化制药专业, 1993年去日本留学,于1997年和1999年分别从吉林大学和日本九州大学各获得医学博士学位,1999-2004年于加拿大麦吉尔(McGill)大学经历博士后训练。2004-2012年作为资深科学家就职于麦吉尔大学生化系。2013年初起任东北大学生命科学与健康学院特聘教授、二级教授,生化与分子生物学研究所所长,为东北大学打造了一只与国际接轨的平台和队伍。2019年入选兴辽特聘教授、2018年获国务院政府特殊津贴、2015年入选辽宁省高端引进人才百人层面沈阳市领军人才、东北大学学术委员会委员、生命科学院教授委员会主任和东北大学三育人先进个人等称号;被国家选为“长江学者、青年长江、国家科学进步奖、国家留学基金” 等评审专家;五年来主持教育部领军人才启动基金、国家自然基金面上两项、参与一项重点专项和辽宁省重点研发一项。

       汪冰教授近十年来通过系统生物学、分子生物学和模式生物学手段,致力于探索细胞稳态维系机制中的多种网络系统。在蛋白的结合及磷酸化两方面都有较多的经验,填补了国际和国内一些空白。多年来领导和参与了多项前沿课题,并多次在国际会议上进行大会发言;其研究成果多数以第一或通讯作者发表于Cell》,《EMBO J》,《MCB》等国际一流杂志上40余篇,其中10篇代表作影响因子之和近100主编《生物化学》教材。


第一或责任作者SCI代表作:


  1. Yang Yu, Bin Bai, Jiahui Zhao, Yanjiao Zhao, Xiaonan Zhang, Tao Wang, Na Zhang, Xipeng Wang, Jialin Xu, Bing Wang*. The Effects of PTP-PEP on the Expression of TCR by regulating its intracellular trafficking. Journal of Immunology. 2020. (revised)


  1. Qing Yuan1, Bo Zhao1, Yu-hua Cao1, Jia-cheng Yan1, Li-jun Sun1, Xia Liu1, Yang Xu1, Xiao-yu Wang, Bing Wang*. BAP31 regulated polarization of macrophages through C/EBP b in cutaneous wound healing. Cellular & Molecular Immunology. 2020. (revised)


  1. Xia Liu, Qing Yuan, Guo-xun Li, Cong-cong Jia, Jingyu-Liu, Ji-kai Xu, Xiao-yu Wang, Yue Hou, Bing Wang*. Regulation of oxygen species by BAP31 through its effect on p22phox and keap1/Nrf2/HO-1 signaling pathway in microglia. Oxidative Medicine and Cellular Longevity. 2020. (accepted)


  1. Tianye Li, Yang Yu, Hang Shi, Yuhua Cao, Xiangfu Liu, Zhenzhen Hao, Yuping Ren, Gaowu Qin, Yongye Huang, Bing Wang. Magnesium in combinatorial with valproic acid suppressed the proliferation and migration of human bladder cancer cells. Frontiers in Oncology. 2020. (accepted)


  1. ZhangX, Wang X, WangT, Bai B, Zhang N, Zhao Y, Yu Y, Wang B*. Efficient delivery of triptolide plus miR-30-5p inhibitor by use of modified MSNs has therapeutic efficacy in rheumatoid arthritis. Frontiers in Bioengineering and Biotechnology. 2020; 8:170.


  1. JiaC, LiG, JiangR, LiuX, YuanQ, LeW, HouY, Wang B. B-cell receptor associated protein31 negatively regulates the expression of monoamine oxidase A via R1. Frontiers in molecular biosciences. 2020 Apr 30;7:64. 


  1. Xiaonan Zhang, Yang Yu, Bin Bai, Tao Wang, Jiahui Zhao, Na Zhang, Yanjiao zhao, Xipeng Wang, Bing Wang*. PTPN22 interacts with EB1 to regulate T cell 1 receptor signaling. The FASEB Journal. 2020 May 29. doi: 10.1096/fj.201902811RR


  1. Liu X, Jiao K, Jia CC, Li GX, Yuan Q, Xu JK, Hou Y, Wang B*.BAP31 regulates IRAK1-dependent neuroinflammation in microglia.J Neuroinflammation. 2019 Dec 28;16(1):281.


  1. Wang TChen JHou YYu YWang B. BAP31 deficiency contributes to the formation of amyloid-βplaques in Alzheimer’s disease by reducing the stability of RTN3. The Faseb Journal. 2019 Apr;33(4):4936-4946. 


  1. Chen J, Guo H, Jiang H, Namusamba M, Wang C, Lan T, Wang T, Wang B. A BAP31 intrabody induces gastric cancer cell death by inhibiting p27kip1 proteasome degradation. International journal of cancer. 2019 Apr 15;144(8):2051-2062.


  1. Jia CC, Du J, Liu X, Jiang R, Huang Y, Wang T, Hou Y, Wang B. B-Cell Receptor-Associated Protein 31 Regulates the Expression of Valosin-Containing Protein Through Elf2. Cell Physiol Biochem. 2018;51(4):1799-1814. 


  1. Jialin Xu, Liya Li, Yanqing Wang, Mu shan, Yaqi Li, Shizhuo Sun, Kunwei Niu,Yang Yu, Bing Wang*. Hepatocyte-Specific Deletion of BAP31 Promotes SREBP1C Activation and Aggravates Liver Steatosis and Insulin Resistance in Mice. The Journal of Lipid Research. 2018 Jan;59(1):35-47


  1. Hou Y, Li G, Wang J, Pan Y, Jiao K, Du J, Chen R, Wang B*, Li N. Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways. Sci Rep. 2017 Apr 3;7:45705. doi: 10.1038/srep45705.


  1. Niu K, Xu J, Cao Y, Hou Y, Shan M, Wang Y, Xu Y, Sun M, Wang B*. BAP31 is involved in T cell activation through TCR signal pathways. Sci Rep. 2017 Mar 23;7:44809. doi: 10.1038/srep44809.


  1. Huang Y, Yuan L, Li T, Liu X, Yu Y, Ouyang H, Wang B*. IWP2 impairs the development of  porcine somatic cell nuclear transfer embryos via Wnt signaling pathway inactivation. Biomed Rep. 2017 Jul;7(1):36-40.


  1. Hou Y, Xie G, Liu X, Li G, Jia C, Xu J, Wang B*. Minocycline protects against lipopolysaccharide-induced cognitive impairment in mice. Psychopharmacology . 20162335):905-916.


  1. Huang Y, Yuan L, Li T, Wang A, Li Z, Pang D, Wang B*, Ouyang H. Valproic Acid Improves Porcine Parthenogenetic Embryo Development Through Transient Remodeling of Histone Modifiers. Cell Physiol Biochem. 2015;37(4):1463-73.doi:10.1159/000438515. Epub 2015 Oct 29.


  1. Huang Y, Li Z, Wang A, Han X, Song Y, Yuan L, Li T, Wang B*, Lai L, Ouyang H, Pang D. Chimerism in piglets developed from aggregated cloned embryos. FEBS Open Bio. 2016 Mar 15;6(4):285-302.


  1. Yue HouNing LiGuanbo XieJian WangQing YuanCongcong JiaXia LiuGuoxun LiYingzhan TangBing Wang*. Pterostilbene exerts anti-neuroinflammatory effect on lipopolysaccharide-activated microglia via inhibition of MAPK signalling pathways. Journal of Functional Foods. 2015; 19:676-687.


  1. Wang T, Jiang H, Wan L, Zhao Q, Jiang T, Wang B*, Wang S. Potential application of functional porous TiO2 nanoparticles in light-controlled drug release and targeted drug delivery. Acta Biomater. 2015 Feb;13:354-63.


  1. Wang T, Zhao P, Zhao Q, Wang B*, Wang S. The mechanism for increasing the oral bioavailability of poorly water-soluble drugs using uniform mesoporous carbon spheres as a carrier. Drug Deliv. 2016232):420-428.


  1. Wang B., Nguyen M, Chang N.C, Shore G.C. Fis1, Bap31 and the kiss of death between mitochondria and endoplasmic reticulum. EMBO J. 2011, 2;30 (3):  451-2


  1. Wang B., Heath-Engel H., Zhang D., Nguyen N, Thomas D.Y., Hanrahan J.W. and Shore G.C. BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRDeltaF508 via the derlin-1 complex. Cell 2008,133(6), 1080-92.


  1. Wang, B., Pelletier, J., Massaad, M.J., and Shore, G.C. Yeast Split-ubiquitin Membrane Protein Two-hybrid Screen Identifies BAP31 as a Regulator of the Turnover of Endoplasmic Reticulum-asssociated Protein Tyrosine Phosphatase-like B  Mol. Cell. Biol. Apr;24(7): 2767-78.  (2004). IF 7.5)(41

  2. Wang, B., Nguyen, M. and Shore, G.C. Uncleaved BAP31 in association with A4 protein at the endoplasmic reticulum is an inhibitor of Fas-initiated release of cytochrome c from mitochondria. J Biol Chem. 278, 14461-14468, (2003). IF 5.6)(12


  1. Wang B., Lemay S., Tsai S. and Veillette A. SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF. Mol. Cell. Biol. 21, 1077-1088, (2001). IF 8.5)(44


  1. Wang BKishihara K.Zhang DL.Nomoto KTranscriptional regulationof a receptor protein tyrosine phosphatase gene hPTP-J by PKC-mediatedsignalling pathways in Jurkat Molt-4 lymphoma cells.Biochimica et Biophysica Acta1999 1450331-340. IF 3.4)(6

    1. .


  1. Wang BKishihara KZhang DLHara HNomoto KMolecular cloning andcharacterization of a novel human receptor protein tyrosine phosphatase gene,hPTP-J down-regulation of the gene expression by PMA and calcium ionophore in Jurkat T lymphoma cells.Biochem. Biophys. Res. Commun.199723177-81. IF 3.5)(4