郝爽

时间:2020-04-15浏览:24

郝爽

博士,教授,博士生导师

东北大学“海外百人计划”青年特聘教授


教育和工作经历

2002-2006河北工业大学,生物工程专业,学士

2006-2012大连理工大学,环境科学与生命学院,生物化工专业,神经药理学博士

2012-2019美国贝勒医学院/德州儿童医院Jan and Dan Duncan神经科学研究所,神经病学,博士后

2019-至今 东北大学生命科学与健康学院,教授,博士生导师


主要研究方向

本课题组主要研究方向集中在神经科学领域中的脑重大疾病的机理和治疗。将神经病学、神经生物学等基础研究与临床治疗相结合,采用多学科交叉融合的方法揭示神经发育障碍和神经退行性疾病等神经系统疾病的发病机制,探讨可行性临床治疗方法,为实现脑疾病的精准医疗提供理论和实践支持。


       本课题组正积极招收相关领域博士后,欢迎加盟!


代表性论文

(1) Shuang Hao, Bin Tang, Zhenyu Wu, Kerstin Ure, Yaling Sun, Huifang Tao, Yan Gao, Akash J. Patel, Daniel J. Curry, Rodney C. Samaco, Huda          Y. Zoghbi&Jianrong Tang. 2015. Forniceal deep brain stimulation rescues hippocampal memory in Rett syndrome mice. Nature. 526: 430-434.

(2) WuChenZhao-Lin CaiEugene S ChaoHongmei ChenColleen M LongleyShuang Hao,Hsiao-Tuan ChaoJoo Hyun KimJessica E MessierHuda Y ZoghbiJianrong TangJohn W SwannMingshan Xue. 2020. Stxbp1/Munc18-1 haploinsufficiency impairs inhibition and mediates key neurological features of STXBP1 encephalopathy. eLIFE. DOI: 10.7554/eLife.48705.

(3) Vincenzo A. Gennarino, Elizabeth E. Palmer, Laura M. McDonell, Li Wang, Carolyn J. Adamski, Christian P. Schaaf, Jill A. Rosenfeld, Jessica A. Panzer, Ute Moog, Shuang Hao, Ann Bye, Edwin P. Kirk, Pawel Stankiewicz, Amy M. Breman, Arran McBride, Tejaswi Kandula, Holly A. Dubbs, Rebecca Macintosh, Michael Cardamone, Ying Zhu, Kevin Ying, Kerith-Rae Dias, Megan T. Cho, Lindsay B. Henderson, Berivan Baskin, Paula Morris, Jiang Tao, Mark J. Cowley, Marcel E. Dinger, Tony Roscioli, OanaCaluseriu, Oksana Suchowersky, Rani K. Sachdev, Olivier Lichtarge, Jianrong Tang, Kym M. Boycott, J. Lloyd Holder, Jr., and Huda Y. Zoghbi. 2018. A Mild PUM1 Mutation Is Associated with Adult-Onset Ataxia, whereas Haploinsufficiency Causes Developmental Delay and Seizures. Cell. 172: 924-936.

(4) Amy E Pohodich, Hari Yalamanchili, Ayush T Raman, Ying-Wooi Wan, Michael Gundry, Shuang Hao, Haijing Jin, Jianrong Tang, Zhandong Liu, Huda Y Zoghbi. 2018, Forniceal deep brain stimulation induces gene expression and splicing changes that promote neurogenesis and plasticity. eLIFE.DOI: 10.7554/eLife.34031.

(5) James P. Orengo, Meike E. van der Heijden, Shuang Hao, Jianrong Tang, Harry T. Orr, and Huda Y. Zoghbi. 2018. Motor neuron degeneration correlates with respiratory dysfunction in SCA1. Dis Model Mech. DOI: 10.1242/dmm.032623.

(6) Cristian A. Lasagna-Reeves, Maria de Haro, Shuang Hao, Jeehye Park, Maxime W.C. Rousseaux, Ismael Al-Ramahi, PaymaanJafar-Nejad, Luis Vilanova-Velez, Lauren See, Antonia De Maio, Larissa Nitschke, Zhenyu Wu, Juan C. Troncoso, Thomas F. Westbrook, Jianrong Tang, Juan Botas and Huda Y. Zoghbi. 2016. Reduction of Nuak1 Decreases Tau And Reverses Phenotypes in a Tauopathy Mouse Model. Neuron. 92: 407-418.

(7) Hui Lu, Ryan T. Ash, Lingjie He, Sara E. Kee, Wei Wang, Dinghui Yu, Shuang Hao, Xiangling Meng, Kerstin Ure, Yaling Sun, Daoyun Ji, Jiangrong Tang, Benjamin R. Arenkiel, Stelios M. Smirnakis, and Huda Y. Zoghbi. 2016. Loss and gain of MeCP2 lead to similar hippocampal circuit abnormalities that are rescued by deep brain stimulation in a Rett syndrome mouse model. Neuron. 91: 739-747.

(8) YehezkelSztainberg, Hong-mei Chen, John W. Swann, Shuang Hao, Bin Tang, Zhenyu Wu, Jianrong Tang, Ying-Wooi Wan, Zhandong Liu, Frank Rigo& Huda Y. Zoghbi. 2015. Reversal of phenotypes in MECP2 duplication mice using genetic rescue or antisense oligonucleotides. Nature. 528: 123-126.

(9) Kihoon Han, J. Lloyd Holder, Jr, Christian P. Schaaf, Hui Lu, Hongmei Chen, Hyojin Kang, Jianrong Tang, ZhenyuWu, Shuang Hao, SauWai Cheung, Peng Yu, Hao Sun, Amy M. Breman, Ankita Patel,Hui-Chen Lu & Huda Y. Zoghbi. 2013. SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. Nature. 503: 72-77.

(10) Shuang Hao, Yong-Ming Bao, Li- Jia An, Wei Cheng, Rong-Guo Zhao, Jing Bi, He- Shuang Wang, Chang- Sen Sun, Ji-Wen Liu, Bo Jiang. 2011. Effects of Resibufogenin and Cinobufagin on voltage-gated potassium channels in primary cultures of rat hippocampal neurons. Toxicol in Vitro. 25: 1644-1653.

(11) Shuang Hao, Yong-Ming Bao, Rong-Guo Zhao, He-Shuang Wang, Jing Bi, Li- jia An, Bo Jiang. 2011. Effects of Resibufogenin on voltage-gated sodium channels in cultured rat hippocampal neurons. Neurosci Lett.501: 112-116.

(12) Aihong Zhang, Shuang Hao, Jing Bi, Yongming Bao, Xiuli Zhang, Lijia An, Bo Jiang. 2009. Effects of catalpol on mitochondrial function and working memory in mice after lipopolysaccharide-induced acute systemic inflammation. Exp ToxicolPathol. 61: 461-469.

(13) Jing Bi, Bo Jiang, Shuang Hao, Aihong Zhang, Yuesheng Dong, Tao Jiang, Lijia An. 2009. Catalpol attenuates nitric oxide increase via ERK signaling pathways induced by rotenone in mesencephalic neurons. Neurochem Int. 54: 264–270

(14) Jing Bi, Xiaobo Wang, Lei Chen, Shuang Hao, Lijia An, Bo Jiang, Lei Guo. 2008. Catalpol protects mesencephalic neurons against MPTP induced neurotoxicity via attenuation of mitochondrial dysfunction and MAO-B activity. Toxicol in Vitro. 22: 1883-1889.

(15) Xiuli Zhang, Bo Jiang, Zhibo Li, Shuang Hao, Lijia An. 2007. Catalpol ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose. PharmacolBiochemBehav. 88: 64-72.

  

联系方式

地址:沈阳市浑南区创新路195号,东北大学生命科学与健康学院生科楼A304-A

邮编:110169

电话:+024-83656108

Email: haoshuang@mail.neu.edu.cn